The controls very rarely get touched.
Feel this. When I first started excitedly jumping down these rabbit holes, I wanted
all the choices because I really didn't know what I wanted so didn't want to leave anything out. I mean, I even got that expensive Positive Grid "Bias Mini" multi amp rig that lets you go so far as to change out the tube types in your amp models—even though I still don't really understand what kind of tube does what in an amp.
Didn't take me too long to realize I had a hefty case of options paralysis, and no freaking clue how to leverage all that power. Even my Quilter Mach II feels like it has too many options these days and I'm actively seeking to trade it for a Mach III with much simpler controls. I found a couple of settings on it that sounded good enough to me and there the knobs stay.
My current practice rig has only a tuner pedal, a Quilter pre-amp box with a cab simulator, and a single klone style OD pedal, feeding into monitor speakers via a Focusrite. The most fiddly it gets is having to remember to turn off the OD and the cab sim when I play an acoustic into it (acoustics sound better to me in FRFR mode on the Quilter block). A bonus with this rig is it's already all set up to feed my DAW if I want to record something. I couldn't begin to describe the tone it produces with my Hollowbody II plugged in, only that I like it well enough to keep it.
