There's no difference in quality or function.
The difference in sound is in "fullness".
Griff is the first person I've found who teaches power chords with the doubled root, i.e. 3 notes using 3 strings.
In the past I've only seen 2 notes, root and 5th using just 2 strings..
Doubling the root will be a "fuller" sound.
The Giant E5 not only doubles the root but doubles it 2 more times = 4.
It also double the 5th.
4 E's and 2 B's.
A lot fuller than just 1 of each using just 2 strings.
Usage depends on the sound you want.
Same with any chord.
You can play a triad with just 3 strings.
Or double up some notes and use all 6 strings.
And add in a bass and keyboard and horns and back-up singers and the entire Morman Tabernacle choir, all playing/singing notes of the triad.
It's still just a triad.
But the sound gets bigger and bigger.
Just ask Phil Spector.
But you'll need to get a Visitor's Pass.