I'm late on this as well, but the forum people are a loyal group and it will be found.
I have rheumatoid arthritis in my left hand; primarily in my thumb and I don't have the squared away reach I used to have. As a result I have learned to fret the chords a bit differently than normal. For example, I cannot do the standard shape for the G major chord.. Instead of using the first, middle and ring finger I fret the G chord with my middle finger on the third fret of the sixth string, ring finger on the second fret of the fifth string and my pinkie on the third fret of the first string. Kind of like a C chord shape. This allows my thumb and wrist to remain relaxed. Barre chords are a challenge as well, but we don't have to use them a lot in blues as there are alternatives. Having said that, the farther up the neck I play the less painful fretting is. One thing I know, I will not stop playing the blues or the guitar. My hand throbs after extended practice but I'll live with it for the joy I get from playing.