After branching out into two pedalboard's worth of stompboxes, I've recently decided to downsize to something more sane,
With the exception of the occasional desire to add a fuzz, a wah or some other "hardly-ever-used" bit of kit -- which turns out to be quite a rare occurrence -- this is what my current board looks like.
Basic four-wire setup with the top row piped into the FX loop while the bottom row goes directly into the preamp.
The three distortion pedals work quite well either alone or in various "stacked" configurations while the EP Boost adds a bit of "pop" when needed.
The HOF (original), the D-seed delay and the Chorus I sometimes use together or individually (or not at all) while the EQ evens out whatever spikes or dropouts that may appear (another rarity) and the Compressor works well with clean tones (sustain) or to add some fullness to whatever crunch I may have dialed in.
Overall, this setup is great for just about every style I can think of playing with the exception of truly hard-core metal (though I do have some additional pedals for that too if the mood strikes).
Nice and simple and it travels well in it's own softcase with a shoulder strap when needed!
No doubt the urge to change things will one day appear, but for now and the foreseeable future this rig satisfies 90% of what I'd ever really need (with the operative phrase being "really need").