Deluxe Reverb is Fender? That said, most Mesa Boogies are best addressed by setting treble first, mid, base and then presense... The treble is the preeminent tone control. In my somewhat limited experience, you're going to be most aggressive with treble, and less so moving down the frequencies. If you want to sculpt the mid more, then you might want to make adjustment to the five band post eq, assuming your amp has one. I often scoop mine, to smooth out my tone, and then drop off the one on the right (sorry can't remember the freq), to deal with 60 cycle hum.